Tangier disease is a condition which reduces the level of high density lipoprotein in blood. The most common symptom of the condition include increased fat in blood, disturbance in nerve function, enlarged and orange tonsils.
What is Tangier Disease?
An inherited condition that significantly reduces levels of high-density lipoprotein (HDL) in the blood is known as Tangier disease. The HDL is required to carry cholesterol and certain fats called phospholipids from the body’s tissues to the liver, where they are removed from the blood. HDL, which is also known as the good cholesterol, can reduce the chances of developing heart and blood vessel disease. Patients of Tangier disease have low HDL levels thus, they are at an increased risk of cardiovascular disease.
Symptoms of Tangier Disease
The signs and symptoms of Tangier disease include:
- Slightly elevated amount of fat in the blood Disturbances in nerve function
- Disturbances in nerve function
- Enlarged, orange coloured tonsils
- Enlarged spleen
- Enlarged liver
- Clouding of the clear covering of the eye
- Type 2 diabetes
How Common is Tangier Disease?
Tangier disease is a rare condition with around 100 cases indentified in the world. Some more cases likely go undiagnosed. This condition was named after an island off the coast of Virginia where the first cases of Tangier disease were indentified.
What are Other Names Used for Tangier Disease?
Other names used Tangier disease are:
- A-alphalipoprotein Neuropathy
- Alpha High Density Lipoprotein Deficiency Disease
- Cholesterol thesaurismosis
- Familial High Density Lipoprotein Deficiency Disease
- Familial Hypoalphalipoproteinemia
- HDL Lipoprotein Deficiency Disease
- Lipoprotein Deficiency Disease, HDL, Familial
- Tangier Disease Neuropathy
- Tangier Hereditary Neuropathy
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Read more on Tangier Disease Signs and Symptoms.
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