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What does the research on Dengue say?

Communicable Diseases By Dr Poonam Sachdev , Expert Content / Apr 06, 2011
What does the research on Dengue say?

Understand Dengue: Vaccine research for dengue was started in the 1940s by Sabin and colleagues. There have been several attempts to make a successful vaccine but this objective has not been realized. Read more!

Vaccine research for dengue was started in the 1940s by Sabin and colleagues. There have been several attempts to make a successful vaccine but this objective has not been realized. We know a lot about virus and disease, but no vaccine has been developed that is approved for use till now.

 

The complexity of dengue vaccine development

 

There are several problems in making a successful dengue vaccine.

  • Dengue is caused by four related types of dengue virus (designated as DEN-1, DEN-2, DEN-3 and DEN-4). For a vaccine to be successful it should induce immunity against all four viruses concurrently.
  • Infection with any type of dengue virus leads to lifelong protective immunity against that particular type of infecting virus (homotypic immunity). However, a secondary infection with any type of dengue virus (e.g. DEN-1 followed by DEN-4) can cause severe and even fatal dengue infection. Hence a major concern is that---will the vaccination lead to potential severe dengue if strong immunity is not developed against all four viruses.

Currently a vaccine is undergoing clinical trial in the USA which will protect against all four dengue viruses, DENV-1, DENV-2, DENV-3 and DENV-4. But the safety and effectiveness of the vaccine remains to be proven.

 

Read articles and Understand dengue

 

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