• shareIcon

The Bad Effects of Good Cholesterol- It May Up Breast Cancer Risk

Latest By Agency News , Agency News / Oct 11, 2013
The Bad Effects of Good Cholesterol- It May Up Breast Cancer Risk

Scientists have found that high levels of 'good cholesterol', known to protect against heart disease, may raise breast cancer risk and enhance cancer aggressiveness.

“Good cholesterol” after all may not be that good. It is known to protect against heart diseases but may up the risk of breast cancer and enhance cancer aggressiveness- scientists have found.

breast cancerThis effect can be a result of a high density lipoprotein (HDL) receptor that is found on breast cancer cells. Researchers have proposed a new molecular target that could help treat the disease.

"If we can block the activity of the HDL receptor in breast cancer, we may be able to limit the harmful effects of HDL, while maintaining levels that are beneficial for blood vessels," said lead researcher Philippe Frank, a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University.

Frank and colleagues exposed breast cancer cell lines to HDL to study its effect on the cancer cells at the molecular level.  They noticed that signalling pathways involved in cancer progression were activated, and that the cells began to migrate in an experimental model mimicking metastasis. 

This study supports the idea that HDL plays a role in the development of aggressive breast cancers and that inhibiting its function via SR-BI in breast cancer cells may stall cancer growth. Additional studies will be needed to develop more specific drugs to inhibit SR-BI.

"Also, we need to understand what levels of cholesterol are required by the tumour before trying to reduce or modify lipid levels in cancer patients," said Frank.

"We hope this study will lead to the development of new drugs targeting SR-BI or cholesterol metabolism and eventually preventing tumour progression," he added.

The study was published in the journal Breast Cancer Research.

 

Read more Health News.

 
Disclaimer:

All possible measures have been taken to ensure accuracy, reliability, timeliness and authenticity of the information; however Onlymyhealth.com does not take any liability for the same. Using any information provided by the website is solely at the viewers’ discretion. In case of any medical exigencies/ persistent health issues, we advise you to seek a qualified medical practitioner before putting to use any advice/tips given by our team or any third party in form of answers/comments on the above mentioned website.

This website uses cookie or similar technologies, to enhance your browsing experience and provide personalised recommendations. By continuing to use our website, you agree to our Privacy Policy and Cookie Policy. OK