How does Obesity Cause Diabetes?

Updated at: Jan 12, 2012
How does Obesity Cause Diabetes?

How does obesity cause Diabetes? Complications associated with diabetes may intensify manifold in overweight individuals, but, how does obesity cause diabetes after-all. Let's find out..

Pratima Sharma
DiabetesWritten by: Pratima SharmaPublished at: Jan 05, 2012

How does obesity cause diabetes

Obesity is not associated with type 1 diabetes where the body is unable to produce insulin. It is, however, considered to be one of the major causes of type 2 diabetes that occurs when insulin is produced normally by the body, but the cell receptors fail to perform adequately for effective utilisation of the same. Furthermore, obesity may also be one of the major causes of cardiovascular ailments such as high cholesterol, clogged arteries, strokes etc. Therefore, complications associated with diabetes may intensify manifold in overweight individuals, but, how does obesity cause diabetes after-all?  Here is how.


How Does Obesity cause Diabetes?


Suppression of IRS


IRS or insulin receptor substrates are proteins, which are present within the cells and are closely linked to insulin receptors. When the receptors are activated by insulin, they release certain chemicals into the IRS, which in turn activate them to transport glucose within the limits of the cell. Recent studies have proved that obesity is in some way linked to the impairment of IRS function and the connecting factor is a hormone called resistin.


The Effect on Resistin


Resistin is a hormone that is produced by the fat cells of the body and is responsible for increasing insulin resistance within the body. Popular belief is that the production of resistin was evolved when mankind had to encounter famine so enough energy could be conserved for future consumption. According to researched facts, the incidence of resistin is considered to be more prevalent in obese individuals; the more the resistin, the greater are the chances of diabetes.


Over Nutrition


Over- nutrition is a condition of the body when there are more fats and calorie reserves in the body than it can process at any given point in time. When the body experiences a state of over- nutrition, the ER or the endoplasmic reticulum, which is a cellular membrane responsible for the processing and synthesizing of blood fats and proteins, is subjected to undue stress. As a result, it sends signals to the insulin receptors so that they refrain from responding to insulin. When such episodes continue to happen repetitively, the body gradually loses its power to respond to insulin thereby making type 2 diabetes a reality.

Once you have found answers to questions like, how does obesity cause diabetes, it would be pertinent to adopt certain control measures for dealing with excess weight. Start off by making healthy food choices and introducing physical activity in your schedule. You can also seek weight loss tips from your doctor, if required.


Read more articles on Diabetes Causes and Risks



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