• shareIcon

Insight into the Genetics of Dengue Virus

Communicable Diseases By Bushra Kafeel , Onlymyhealth editorial team / Jan 05, 2012
Insight into the Genetics of Dengue Virus

In order to understand about the genetics of dengue virus one must know that there are four serotypes of dengue virus. Learn more about it, here.

Dengue virus can cause fever of different severity and in rare cases, lead to complex situation such as dengue hemorrhagic fever.

genetics dengue virus

When the different strains of dengue virus interact with the immune system of different people, it can cause complex interactions resulting in conditions such as dengue hemorrhagic fever or dengue shock syndrome.

 

Genetics of Dengue Virus

The genome of dengue virus consists of seven non-structured proteins and three structural proteins.

 

Non-structural proteins- NS1, NS2a, NS2b, NS3, NS4a, NS4b and NS5

Structural proteins-envelope protein E, membrane protein M and capsid protein C

 

  • E protein- E protein is found on the upper most surface of dengue virus. It is responsible for the initial entrance of virus to the host cell. Other responsible factors for viral entry to the host cell include CD209, Rab 5, GRP 78 and the mannose receptor.
  • prM/M protein- prM (membrane) protein plays an important role in the formation of viral particles. Once the dengue virus is fully formed, it develops 180 copies of E protein and M protein. E protein acts as a shell wherein M protein acts as a transmembrane. The prM/M protein stay closely associated with the formed E protein till the time dengue virus actually enters the extra cellular environment. Moreover, pr peptide covers the loop of e-protein until the viral particles stay inside the cell.
  • NS3 protein- NS3 of dengue virus is serine protease that consists of six β-strands and two β-barrels that are formed by protein residue.
  • NS5 protein- DENV NS5 protein is a residue peptide. It has methyltransferase domain at its N-terminal end and a RNA-dependent RNA polymerase at its C-terminal end.

A person who has been previously infected with dengue is more prone to its severe form. This happens as the antibodies meant for the old strain now start interfering in response of immune to the current restrain, thus facilitating dengue virus entry to the body.

 

Read more articles on Understand Dengue.

 

 

Disclaimer

All possible measures have been taken to ensure accuracy, reliability, timeliness and authenticity of the information; however Onlymyhealth.com does not take any liability for the same. Using any information provided by the website is solely at the viewers’ discretion. In case of any medical exigencies/ persistent health issues, we advise you to seek a qualified medical practitioner before putting to use any advice/tips given by our team or any third party in form of answers/comments on the above mentioned website.

This website uses cookie or similar technologies, to enhance your browsing experience and provide personalised recommendations. By continuing to use our website, you agree to our Privacy Policy and Cookie Policy. OK