Dengue Prevention: How to Prevent Dengue Fever? The best way to prevent dengue virus infection is to take precautions to avoid being bitten by mosquitoes, the Aedes mosquito. Because Aedes mosquitoes usually bite during the day, especially during early morning hours before daybreak and in the late afternoon before dark. You can get rid of the Aedes mosquito in your locality by regularly checking and draining stagnant water in your premises. Read articles on dengue preventive measures.