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Reasons for Low Platelet Count in Dengue Fever

Communicable Diseases
By Bushra Kafeel , Onlymyhealth editorial team / Apr 06, 2011
Reasons for Low Platelet Count in Dengue Fever

There are many causes of low platelet count in dengue fever. Irrespective of the cause of low platelet count it can lead to life threatening conditions if someone is suffering from dengue fever.

Quick Bites
  • Dengue virus can induce bone marrow suppression.
  • Dengue virus can even bind to platelets of human blood.
  • Another reasons is vascular endothelial cells getting infected.
  • Antibodies production after infection is another reason.

Blood platelets also known as thrombocytes play an important role in your body. These cell fragments are natural source of growth and play basic role in process of hemostasis (preventing bleeding from damaged blood vessel) as well.


low platelets


Normal platelet count in a micro litre of human blood is 150000 to 450000. Slight decrease in the platelet count does not contribute to the disease but when it is below 50,000 per micro litre, thrombocytopenia occurs. Low platelet count in dengue fever can be very dangerous.

The reasons for low platelet count in dengue fever are as follows.

  • Dengue virus, the main cause of dengue fever induces bone marrow suppression. Since bone marrow is the manufacturing centre of blood cells its suppression causes deficiency of blood cells leading to low platelet count. Anaemia and spontaneous severe bleeding are the other resultant factors of bone marrow suppression.
  • Studies suggest that dengue virus can even bind to platelets of human blood in the presence of virus-specific antibody.


dengue fever


  • When vascular endothelial cell that are infected with dengue virus gets combined with platelets they tend to destroy platelets. This is one of the major causes of low platelet count in dengue fever.
  • Even the antibodies that are produced after infection of dengue virus can contribute in destruction of platelets, thus lowering the platelet count.



Low platelet count in dengue fever may lead to life-threatening condition known as hemorrhagic dengue fever that is categorised by spontaneous bleeding tendency and shock.


Read more articles on Dengue.

Written by
Bushra Kafeel
Source: Onlymyhealth editorial teamApr 06, 2011

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